When the seven angels who had the seven plagues come out from the Temple of God, they receive from one of
the four living creatures a bowl of God's wrath (Rev 15:6-7), and it
appears that each plague is mixed with each corresponding bowl (Rev 21:9).
The first bowl of God's wrath / plague (Rev 16:2):
1. Poured on the earth.
2. Causes loathsome and malignant sores on people who had the mark of the beast and
worshiped his image.
3. Because the surviving human beings are non-Believers (Rev 9:20-21;
13:8, 16-17), most, if not all, human beings are tormented with
disfiguring and painful sores.