When the seven angels who had the seven plagues come out from the Temple of God, they receive from one of
the four living creatures a bowl of God's wrath (Rev 15:6-7), and it
appears that each plague is mixed with each corresponding bowl (Rev 21:9).
The second bowl / plague (Rev 16:3):
1. Poured into the sea.
2. Causes the seas to became blood and killed all living creatures in it.
3. With the poisoning of all salt water, all seafood becomes unavailable. The second trumpet
had already poisoned 1/3 of all salt water.
In light of the eagle's woe for "those who dwell on the earth" (Rev 8:13;
11:14), the bowl plagues represent the third, last woe, and the only
remaining judgments against those left on earth; they represent the "reaping" by the angel
The reaping figuratively speaks of gathering the "ripe" grapes and throwing them into the great
wine press of God's wrath "outside the city" (Rev 14:18-19), which is a
reference to the bowl judgments (Rev 16:1-21). This period of reaping
includes the angelic assistance of carrying out Jesus Christ's judgment at Armageddon, because it is Jesus who
treads upon the grapes in the great wine press of God's wrath (Rev 19:15-21).