Great Tribulation?

When the elder informs the apostle John that the clothed saints "came out of the great tribulation," it is in reference to the fifth seal that occurred ealier (Rev 6:9).

Jesus prophesized that the Great Tribulation (Matt 24:21; Mark 13:19-20; Luke 21:23-24) will occur when "the abomination of desolation which was spoken of through Daniel the prophet" is standing in the holy place which locates this event in the middle of Daniel's 70th week. Unlike tribulation in general, the Great Tribulation will be a time to flee (Matt 24:15-16; Mark 13:14; Luke 21:20-22)