This first woe is placed within a repetition of woes. It is proclaimed with a sense of sadness, almost like a sympathetic sorrow;
but, there is an emphasis, a declaration of condemnation, with the sense of divine judgment of the evil upon the disbelieving world.
Then I looked, and I heard an eagle flying in midheaven, saying with a loud voice, "Woe, woe, woe to those
who dwell on the earth, because of the remaining blasts of the trumpet of the three angels who are about to sound!"
(Rev 8:13)
Up until to the fifth trumpet, God's wrath of judgment was not focused on causing physical injury upon human beings;
now the last three trumpets will bring torment and death upon all of mankind on earth.